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Dramatic gender-particular transcriptional solutions is recapitulated in mice immediately after CVS

We next assessed whether similarly dramatic sex differences in transcriptional profiles are produced in mice in response to CVS. We found that 21 days of CVS induced a range of depression- and anxiety-related behavioral abnormalities to an equivalent degree in male vs. female mice ( Concord escort reviews Figure 2a–d ). These include increased latency to eat in the novelty-suppressed feeding test (F(1,40)=24.3, p (step 1,40)=8.68, p (1,40)=3.61, p=0.06; Figure 2c ) and decreased sucrose preference (F(1,40)=, p

I used RNAseq to survey the newest transcriptome in two associate notice countries, vmPFC and you will NAc, from 20 people and you may 20 females (half of troubled, 50 % of unstressed control).